This web portal is dedicated to putatively active LINE-1 elements.
LINE-1 (Long Interspersed Nucleotide Element 1, L1) are the only autonomous retrotransposons in the group of non-LTR retrotransposons. They comprise about 18%-20% of mammalian genomes.
Click here for background information and literature on LINE-1 elements.
L1Base 2 is a dedicated database containing putatively active LINE-1 (L1) insertions residing in human and rodent genomes: a) intact in the two ORFs, full length L1s (FLI-L1s) and b) L1s with intact ORF2 but disrupted ORF1 (ORF2-L1s). In addition, due to their regulatory potential, full length non-intact L1s (FLnI-L1s) were also included in the database.
A web interface to the tool for identification and functional annotation of full length L1 insertions, L1Xplorer, has been linked to the site.
Publications involving L1Base
L1Base 2: more retrotransposition-active LINE-1s, more mammalian genomes
Nucleic Acids Res. 2017 Jan 4;45(D1):D68-D73. doi: 10.1093/nar/gkw925
L1Base: from functional annotation to prediction of active LINE-1 elements
Nucl. Acids Res. 2004 33: D498-D500; doi:10.1093/nar/gki044